{"product_id":"5-htp","title":"5-HTP","description":"\u003cp\u003e\u003clink rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\"\u003e \u003clink rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin=\"\"\u003e \u003clink href=\"https:\/\/fonts.googleapis.com\/css2?family=Lora:ital,wght@0,400;0,600;0,700;1,400\u0026amp;family=Inter:wght@300;400;500;600\u0026amp;family=Nunito:wght@600;700;800\u0026amp;display=swap\" rel=\"stylesheet\"\u003e\u003c\/p\u003e\n\u003cstyle\u003e\n  .mp-accordion-wrap { max-width: 1200px; margin: 0 auto; padding: 2rem 1rem; font-family: 'Inter', sans-serif; color: #003D3D; line-height: 1.6; }\n  .mp-intro { background: linear-gradient(135deg, #F9F5E8 0%, #D6F0EE 100%); padding: 20px; border-radius: 8px; margin-bottom: 1.5rem; border-left: 4px solid #C9952B; }\n  .mp-intro p { color: #003D3D; line-height: 1.8; font-size: 14px; font-weight: 500; margin-bottom: 0.5rem; }\n  .mp-intro p:last-child { margin-bottom: 0; }\n  .mp-intro .mp-benefit-headline { font-family: 'Lora', Georgia, serif; 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border-left: 4px solid #C9952B; padding: 20px; border-radius: 8px; margin: 1.25rem 0; }\n  .mp-callout p { font-size: 14px; color: #003D3D; margin: 0; line-height: 1.8; }\n  .mp-ingredients-box { background: linear-gradient(135deg, #F9F5E8 0%, #D6F0EE 100%); padding: 24px; border-radius: 8px; margin-top: 1rem; }\n  .mp-ing-label { display: block; font-family: 'Nunito', sans-serif; font-size: 12px; font-weight: 800; color: #C9952B; text-transform: uppercase; letter-spacing: 0.5px; margin-bottom: 6px; margin-top: 16px; }\n  .mp-ing-label:first-child { margin-top: 0; }\n  .mp-ingredients-box p { font-size: 13px; color: #003D3D; margin: 0; line-height: 1.7; font-weight: 400; }\n  .mp-ing-divider { border: none; border-top: 1px solid #D6F0EE; margin: 16px 0 0; }\n  @media (max-width: 968px) { .mp-accordion-wrap { padding: 1rem 0.5rem; } }\n\u003c\/style\u003e\n\u003cdiv class=\"mp-accordion-wrap\"\u003e\n\u003cdiv class=\"mp-intro\"\u003e\n\u003cspan class=\"mp-naysa-badge\"\u003eQuality Vetted · by NAYSA\u003c\/span\u003e \u003cspan class=\"mp-benefit-headline\"\u003eYour body’s own serotonin pathway — gently supported from within.\u003c\/span\u003e\n\u003cp class=\"mp-benefit-sub\"\u003e5-Hydroxytryptophan from Griffonia simplicifolia seed. Supports mood balance, restful sleep, healthy appetite, and muscle comfort. Two capsules daily, 20–30 minutes before a meal. Clean four-ingredient formula.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"mp-why-card\"\u003e\n\u003cdiv class=\"mp-why-heading\"\u003eWhy We Chose This\u003c\/div\u003e\n\u003cp\u003eSerotonin is one of the brain’s most important signaling molecules — influencing mood, sleep, appetite, and how we experience physical comfort. The body makes serotonin from tryptophan, an amino acid found in food. But tryptophan has to compete with many other amino acids for transport across the blood-brain barrier, which limits how much actually reaches the brain. 5-HTP bypasses that competition entirely. As the direct metabolic step between tryptophan and serotonin, 5-HTP crosses the blood-brain barrier readily and converts to serotonin with high efficiency. That’s why it’s a more targeted approach than tryptophan supplementation alone. We chose the Griffonia simplicifolia source specifically — it’s the most well-researched plant-based source of 5-HTP, with a long track record of use in clinical studies on mood, sleep, and appetite regulation. The formula is intentionally minimal: 5-HTP, Calcium (as a cofactor that supports serotonin synthesis), and clean capsule excipients. No synthetic additives, no proprietary blends, no unnecessary fillers. This is a sensitive category — mood support deserves a clean, honest formula. One important note: because 5-HTP directly influences serotonin levels, it is not appropriate for everyone. Anyone taking prescription antidepressants, SSRIs, or MAOIs should consult their physician before use. We’ve made this prominent in our safety section because it matters.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdetails class=\"mp-accordion\"\u003e\n\u003csummary\u003e\u003cspan\u003eDescription\u003c\/span\u003e\u003cspan class=\"mp-icon\"\u003e▼\u003c\/span\u003e\u003c\/summary\u003e\n\u003cdiv class=\"mp-accordion-body\"\u003e\n\u003cp\u003e5-HTP (5-Hydroxytryptophan) is the immediate precursor to serotonin — the neurotransmitter that plays a central role in emotional balance, sleep quality, appetite regulation, and physical comfort. Unlike tryptophan, 5-HTP crosses the blood-brain barrier efficiently and converts directly to serotonin, making it one of the most targeted natural approaches to serotonin support available.\u003c\/p\u003e\n\u003cp\u003eSourced from Griffonia simplicifolia seed — the most clinically studied plant-based source of 5-HTP — this clean, four-ingredient formula supports a balanced mood, restful sleep, healthy satiety signals, and muscle comfort. Two capsules daily, taken before a meal.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eNote:\u003c\/strong\u003e 5-HTP has important interactions with certain medications. Please read the Safety Information section carefully before use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"mp-accordion\"\u003e\n\u003csummary\u003e\u003cspan\u003eWhat This Supports\u003c\/span\u003e\u003cspan class=\"mp-icon\"\u003e▼\u003c\/span\u003e\u003c\/summary\u003e\n\u003cdiv class=\"mp-accordion-body\"\u003e\n\u003cdiv class=\"mp-cards\"\u003e\n\u003cdiv class=\"mp-card\"\u003e\n\u003ch4\u003eMood \u0026amp; Emotional Balance\u003c\/h4\u003e\n\u003cp\u003eSupports normal serotonin production to help maintain a positive outlook, emotional resilience, and a sense of calm well-being throughout the day.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"mp-card\"\u003e\n\u003ch4\u003eRestful Sleep\u003c\/h4\u003e\n\u003cp\u003eSerotonin is a precursor to melatonin — the hormone that regulates sleep cycles. 5-HTP supplementation may support natural sleep onset and sleep quality.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"mp-card\"\u003e\n\u003ch4\u003eAppetite \u0026amp; Weight Management\u003c\/h4\u003e\n\u003cp\u003eSerotonin plays a role in satiety signaling. 5-HTP has been studied for its potential to support healthy appetite regulation and promote feelings of fullness.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"mp-card\"\u003e\n\u003ch4\u003eMuscle Comfort\u003c\/h4\u003e\n\u003cp\u003eSerotonin is present in muscle tissue and plays a role in regulating muscular comfort and relaxation, supporting improved daily physical function.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"mp-accordion\"\u003e\n\u003csummary\u003e\u003cspan\u003eHow 5-HTP Works\u003c\/span\u003e\u003cspan class=\"mp-icon\"\u003e▼\u003c\/span\u003e\u003c\/summary\u003e\n\u003cdiv class=\"mp-accordion-body\"\u003e\n\u003cp\u003e5-HTP works by providing the brain with a direct, highly bioavailable precursor to serotonin — one step closer to the finished neurotransmitter than dietary tryptophan. Understanding the pathway helps explain why it supports such a wide range of functions.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe Serotonin Pathway:\u003c\/strong\u003e Dietary tryptophan → 5-HTP → Serotonin → Melatonin. 5-HTP occupies the critical middle step. It crosses the blood-brain barrier without competing with other amino acids, and is rapidly converted to serotonin by the enzyme aromatic L-amino acid decarboxylase. This makes supplementation efficient and predictable.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMood \u0026amp; Emotional Balance:\u003c\/strong\u003e Serotonin is the primary neurotransmitter associated with mood regulation, emotional stability, and a sense of well-being. Supporting healthy serotonin levels through 5-HTP has been the subject of numerous clinical studies on mood and emotional balance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSleep — Serotonin to Melatonin Conversion:\u003c\/strong\u003e In the pineal gland, serotonin is converted to melatonin by two enzymatic steps. Adequate serotonin availability is a prerequisite for healthy melatonin production. By supporting serotonin levels, 5-HTP can help support the body’s natural sleep-wake cycle.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAppetite Regulation:\u003c\/strong\u003e Serotonin produced in the gastrointestinal tract plays a key role in satiety signaling. Higher serotonin activity in the gut is associated with reduced food intake and a greater sense of fullness, which is why 5-HTP has been studied in the context of appetite and weight management.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCalcium as Cofactor:\u003c\/strong\u003e The conversion of 5-HTP to serotonin requires the enzyme aromatic amino acid decarboxylase, which depends on pyridoxal phosphate (B6) and functions optimally in the presence of calcium. Calcium Carbonate is included in this formula to support the enzymatic conversion pathway.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"mp-accordion\"\u003e\n\u003csummary\u003e\u003cspan\u003eHow to Use\u003c\/span\u003e\u003cspan class=\"mp-icon\"\u003e▼\u003c\/span\u003e\u003c\/summary\u003e\n\u003cdiv class=\"mp-accordion-body\"\u003e\n\u003cdiv class=\"mp-callout\"\u003e\n\u003cp\u003e\u003cstrong\u003eSuggested Use:\u003c\/strong\u003e Take two (2) capsules once daily as a dietary supplement. For best results, take 20–30 minutes before a meal with an 8 oz (236 ml) glass of water, or as directed by your healthcare professional.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003eTaking before a meal on a relatively empty stomach improves absorption — food competition is reduced when the stomach isn’t processing a full meal\u003c\/li\u003e\n\u003cli\u003eIf sleep support is the primary goal, consider taking before your evening meal or 1–2 hours before bed to support the serotonin-to-melatonin conversion cycle\u003c\/li\u003e\n\u003cli\u003eAllow 2–4 weeks of consistent daily use for mood and sleep benefits to build to their full effect\u003c\/li\u003e\n\u003cli\u003eDo not take with other serotonergic supplements (such as St. John’s Wort) or medications without physician guidance — see Safety Information\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"mp-accordion\"\u003e\n\u003csummary\u003e\u003cspan\u003eIngredients\u003c\/span\u003e\u003cspan class=\"mp-icon\"\u003e▼\u003c\/span\u003e\u003c\/summary\u003e\n\u003cdiv class=\"mp-accordion-body\"\u003e\n\u003cdiv class=\"mp-ingredients-box\"\u003e\n\u003cspan class=\"mp-ing-label\"\u003eActive Ingredients\u003c\/span\u003e\n\u003cp\u003eCalcium (as Calcium Carbonate), 5-Hydroxytryptophan (from Griffonia simplicifolia seed extract).\u003c\/p\u003e\n\u003chr class=\"mp-ing-divider\"\u003e\n\u003cspan class=\"mp-ing-label\"\u003eOther Ingredients\u003c\/span\u003e\n\u003cp\u003eGelatin (capsule), Magnesium Stearate.\u003c\/p\u003e\n\u003chr class=\"mp-ing-divider\"\u003e\n\u003cspan class=\"mp-ing-label\"\u003eQuality Standards\u003c\/span\u003e\n\u003cp\u003e5-HTP sourced from Griffonia simplicifolia seed — the most clinically studied plant-based source. Calcium included as an enzymatic cofactor for serotonin synthesis. Clean four-ingredient formula. No synthetic dyes, artificial flavors, or proprietary blends. Capsule shell is bovine gelatin — not vegan. Selected by MirthPlus and vetted for our quality standards.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"mp-accordion\"\u003e\n\u003csummary\u003e\u003cspan\u003eSafety Information\u003c\/span\u003e\u003cspan class=\"mp-icon\"\u003e▼\u003c\/span\u003e\u003c\/summary\u003e\n\u003cdiv class=\"mp-accordion-body\"\u003e\n\u003cdiv class=\"mp-warning-critical\"\u003e\n\u003cp\u003e\u003cstrong\u003e⚠ Critical — Medication Interactions:\u003c\/strong\u003e 5-HTP directly influences serotonin levels in the brain. Taking 5-HTP alongside antidepressants, SSRIs (such as fluoxetine, sertraline, escitalopram), SNRIs, MAOIs, or other serotonergic medications can cause a potentially serious condition known as \u003cstrong\u003eSerotonin Syndrome\u003c\/strong\u003e. Do NOT use this product if you are currently taking any of these medications without explicit physician approval and supervision.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e⚠ SSRIs \u0026amp; Antidepressants:\u003c\/strong\u003e Combining 5-HTP with SSRIs, SNRIs, tricyclic antidepressants, or MAOIs significantly increases the risk of serotonin syndrome. If you are on any prescription medication for mood, anxiety, or depression, consult your physician before use — this is not optional.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e⚠ St. John’s Wort \u0026amp; Other Serotonergic Supplements:\u003c\/strong\u003e Do not combine with St. John’s Wort, SAMe, L-Tryptophan, or other supplements that influence serotonin without physician guidance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e⚠ Pregnancy \u0026amp; Nursing:\u003c\/strong\u003e Not recommended during pregnancy or nursing. Serotonin plays an important developmental role; supplementation is not appropriate without direct physician supervision.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e⚠ Parkinson’s Disease:\u003c\/strong\u003e Individuals taking carbidopa (used in Parkinson’s treatment) should not use 5-HTP without physician approval, as the combination may cause nausea or other adverse effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e⚠ Surgery:\u003c\/strong\u003e Discontinue use at least two weeks before any scheduled surgery, as 5-HTP may interact with anesthetic and pain medications used during surgical procedures.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e⚠ Children:\u003c\/strong\u003e Not intended for use by children under 18. Keep out of reach of children.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e⚠ Storage:\u003c\/strong\u003e Store in a cool, dry place away from direct sunlight. Do not use if the safety seal is damaged or missing.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv class=\"mp-warning\"\u003e\n\u003cp\u003e\u003cstrong\u003e⚠ General Notice:\u003c\/strong\u003e Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"mp-accordion\"\u003e\n\u003csummary\u003e\u003cspan\u003eShipping Information\u003c\/span\u003e\u003cspan class=\"mp-icon\"\u003e▼\u003c\/span\u003e\u003c\/summary\u003e\n\u003cdiv class=\"mp-accordion-body\"\u003e\n\u003cp\u003e\u003cstrong\u003eFree Shipping:\u003c\/strong\u003e On all orders over $50 within the continental United States.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eProcessing Time:\u003c\/strong\u003e Most orders ship within 1–2 business days (Monday–Friday). Weekend and holiday orders ship the next business day.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDelivery Time:\u003c\/strong\u003e Standard shipping takes 3–7 business days after processing. You’ll receive tracking by email once your order ships.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuestions?\u003c\/strong\u003e Reach us at info@mirthplus.com or call 619-512-3151.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003cdetails class=\"mp-accordion\"\u003e\n\u003csummary\u003e\u003cspan\u003eReturn \u0026amp; Refund Policy\u003c\/span\u003e\u003cspan class=\"mp-icon\"\u003e▼\u003c\/span\u003e\u003c\/summary\u003e\n\u003cdiv class=\"mp-accordion-body\"\u003e\n\u003cp\u003e\u003cstrong\u003e30-Day Happiness Guarantee:\u003c\/strong\u003e If you’re not satisfied, return your purchase within 30 days of receipt — no runaround.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eReturn Conditions:\u003c\/strong\u003e Unopened products in original packaging qualify for a full refund. Opened products may be eligible for exchange or store credit on a case-by-case basis.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow to Return:\u003c\/strong\u003e Email info@mirthplus.com with your order number and reason for return. We’ll send return instructions and authorization.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eRefund Processing:\u003c\/strong\u003e Refunds processed within 5–7 business days of receiving your return, back to your original payment method.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/details\u003e\n\u003c\/div\u003e","brand":"MirthPlus","offers":[{"title":"Default Title","offer_id":41757221748869,"sku":"NNU-CapsMood5HTP","price":19.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0321\/1205\/0309\/files\/1757040035367-generated-label-image-0.webp?v=1783630858","url":"https:\/\/mirthplus.com\/products\/5-htp","provider":"MirthPlus","version":"1.0","type":"link"}